Crohn’s Disease

Crohn’s disease is a chronic inflammatory bowel disease. This disease affects people of all ages and the onset is set usually in childhood or early adulthood. The real causes of Crohn’s disease are still unknown and despite the advances in medications, a cure is yet to be found. Factors such as immune system status, genetic predisposition or environmental triggers can influence the onset and course of the disease.


Diagnosis of Real Causes & Treatment of Crohn Disease

  • Gradual restoration of cellular function
  • Personalized therapeutic protocols, without chemical residues and excipients
  • Treating the real causes
  • Therapeutic formulas that work alone or in combination with any other medication
  • Adopting a Molecular / Therapeutic Nutrition Plan



Crohn’s manifestations range from mild to debilitating. The symptoms can include abdominal pain, diarrhea, fever, fatigue, dehydration, frequent bowel movements, weight loss, reduced appetite, blood in the stool or hemorrhoids.

Your Health Specialist will address a series of targeted questions to you, to assess whether your symptoms could be indicative of Crohn’s disease. Then your specialist may recommend a specialized blood test, a stool sample analysis or other molecular-level diagnostic tests to confirm the diagnosis. Your personalized treatment plan will be based upon the diagnostic tests results, the symptoms described and your medical history overall.


This treatment plan will be accompanied by a Molecular Nutrition program that will be compiled after a distinct consultation with our Molecular Nutritionist and will aim towards achieving even higher levels of health and well-being along with alleviating not only the symptoms but the true causes of Crohn’s disease.



Dr. Nikoleta Koini, M.D.

Doctor of Functional, Preventive, Anti-ageing and Restorative Medicine.

Diplomate and Board Certified in Anti-aging, Preventive, Functional and Regenerative Medicine from A4M (American Academy in Antiaging Medicine).

Functional Corporation


  • Sartor RB. Mechanisms of disease: pathogenesis of Crohn’s disease and ulcerative colitis. Nat Clin Pract Gastroenterol Hepatol. 2006;3(7): 390–407.
  • Itta M. Minderhoud, Bas Oldenburg, Marguerite E.I. Schipper, Jose – J.M. ter Linde, Melvin Samson. Serotonin Synthesis and Uptake in Symptomatic Patients with Crohn’s Disease in Remission. Clinical Gastroenterology and Hepatology. June 2007
  • R. Spiller. Recent advances in understanding the role of serotonin in gastrointestinal motility in functional bowel disorders: alterations in 5-HT signaling and metabolism in human disease. Neurogastroenterology and Motility. Jul. 2007
  • Jean-Eric Ghia, Nan Li, Huaqing Wang et al. Serotonin has a key role in pathogenesis of experimental colitis. Gastroenterology. Nov 2009
  • Stein, A., Hinz, M., & Uncini, T. (2010). Amino acid-responsive Crohn’s disease: a case study. Clinical and experimental gastroenterology, 3, 171.
  • Hinz, M., Stein, A., & Uncini, T. (2012). Relative nutritional deficiencies associated with centrally acting monoamines. Int J Gen Med, 5, 413-430.Loddo I, Romano C. Inflammatory bowel disease: genetics, epigenetics, and pathogenesis. Frontiers in immunology. 2015 Nov 2;6:551. Ni J, Wu GD, Albenberg L, Tomov VT. Gut microbiota and IBD: causation or correlation?. Nature reviews Gastroenterology & hepatology. 2017 Oct;14(10):573.
  • Liu TC, Stappenbeck TS. Genetics and pathogenesis of inflammatory bowel disease. Annual Review of Pathology: Mechanisms of Disease. 2016 May 23;11:127-48.
  • De Souza HS, Fiocchi C. Immunopathogenesis of IBD: current state of the art. Nature reviews Gastroenterology & hepatology. 2016 Jan;13(1):13.
  • Davies JM, Abreu MT. The innate immune system and inflammatory bowel disease. Scandinavian Journal of Gastroenterology. 2015 Jan 2;50(1):24-33.
  • Zhao M, Burisch J. Impact of genes and the environment on the pathogenesis and disease course of inflammatory bowel disease. Digestive diseases and sciences. 2019 Jul 15;64(7):1759-69.
  • Knight-Sepulveda K, Kais S, Santaolalla R, Abreu MT. Diet and inflammatory bowel disease. Gastroenterology & hepatology. 2015 Aug;11(8):511.
  • Lewis JD, Abreu MT. Diet as a trigger or therapy for inflammatory bowel diseases. Gastroenterology. 2017 Jan 1;152(2):398-414.
  • Bernstein CN. Psychological stress and depression: risk factors for IBD?. Digestive Diseases. 2016;34(1-2):58-63.
  • Bernstein CN. The brain-gut axis and stress in inflammatory bowel disease. Gastroenterology Clinics. 2017 Dec 1;46(4):839-46.
  • Tontini GE, Vecchi M, Pastorelli L, Neurath MF, Neumann H. Differential diagnosis in inflammatory bowel disease colitis: state of the art and future perspectives. World journal of gastroenterology: WJG. 2015 Jan 7;21(1):21.  Ananthakrishnan AN. Epidemiology and risk factors for IBD. Nature reviews Gastroenterology & hepatology. 2015 Apr;12(4):205-17.
  • Pituch-Zdanowska A, Banaszkiewicz A, Albrecht P. The role of dietary fibre in inflammatory bowel disease. Przeglad gastroenterologiczny. 2015;10(3):135.