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Sjögren Syndrome

Sjögren’s syndrome is an autoimmune pathological condition that primarily affects the mucous membranes and moisture-secreting glands of the eyes and mouth. This syndrome affects more women than men and is usually diagnosed in people over the age of 40. Sjögren’s syndrome sometimes co-exists with other autoimmune disorders, such as Rheumatoid arthritis and Lupus.

 

Diagnosis of Real Causes & Treatment of Sjögren Syndrome

  • Gradual restoration of cellular function
  • Personalized therapeutic protocols, without chemical residues and excipients
  • Treating the real causes
  • Therapeutic formulas that work alone or in combination with any other medication
  • Adopting a Molecular / Therapeutic Nutrition Plan

 

Sjogren

The symptoms that patients with Sjögren’s syndrome experience, include eye dryness, mouth-throat dryness, difficulty in swallowing, vaginal dryness, swelling of the salivary glands (swelling of the area between jaws and the ears), increase of dental cavities or skin rashes.

Your Health Specialist will address a series of targeted questions to you, to assess whether your symptoms could be indicative of Sjögren’s Syndrome. Then your specialist may recommend a specialized blood or antibodies test, an eye examination or other molecular-level diagnostic tests to confirm the diagnosis. Your personalized treatment plan will be based upon the diagnostic tests results, the symptoms described and your medical history overall.

 

This treatment plan may be accompanied by a Molecular Nutrition program that will be compiled after a distinct consultation with our Molecular Nutritionist and will aim towards achieving even higher levels of health and well-being, along with alleviating not only the symptoms but the true causes of Sjögren’s Syndrome.

 

 

Dr. Nikoleta Koini, M.D.

Doctor of Functional, Preventive, Anti-ageing and Restorative Medicine.

Diplomate and Board Certified in Anti-aging, Preventive, Functional and Regenerative Medicine from A4M (American Academy in Antiaging Medicine).

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Functional Corporation

References


  • Moutsopoulos HM. Sjögren’s syndrome: autoimmune epithelitis. Clin Immunol Immunopathol (1994) 72(2):162–5.10.1006/clin.1994.1123
  • Ramos-Casals M, Brito-Zerón P, Kostov B, Sisó-Almirall A, Bosch X, Buss D, et al. Google-driven search for big data in autoimmune geoepidemiology: analysis of 394,827 patients with systemic autoimmune diseases. Autoimmun Rev (2015) 14(8):670–9.10.1016/j.autrev.2015.03.008
  • Humphreys-Beher MG, Brinkley L, Purushotham KR, Wang PL, Dusek D, Nakagawa Y, et al. Characterization of antinuclear autoantibodies present in the serum from nonobese diabetic (NOD) mice. Clin Immunol Immunopathol (1993) 68:350–6.10.1006/clin.1993.1137
  • Humphreys-Beher MG, Hu Y, Nakagawa Y, Wang PL, Purushotham KR. Utilization of the non-obese diabetic (NOD) mouse as an animal model for the study of secondary Sjogren’s syndrome. Adv Exp Med Biol (1994) 350:631–6.10.1007/978-1-4615-2417-5_105
  • Robinson CP, Yamamoto H, Peck AB, Humphreys-Beher MG. Genetically programmed development of salivary gland abnormalities in the NOD (nonobese diabetic)-scid mouse in the absence of detectable lymphocytic infiltration: a potential trigger for sialoadenitis of NOD mice. Clin Immunol Immunopathol (1996) 79:50–9.10.1006/clin.1996.0050
  • de Paiva CS, Jones DB, Stern ME, Bian F, Moore QL, Corbiere S, et al. Altered mucosal microbiome diversity and disease severity in Sjögren syndrome. Sci Rep (2016) 6:23561.10.1038/srep23561
  • Spachidou MP, Bourazopoulou E, Maratheftis CI, Kapsogeorgou EK, Moutsopoulos HM, Tzioufas AG. Expression of functional toll-like receptors by salivary gland epithelial cells: increased mRNA expression in cells derived from patients with primary Sjogren’s syndrome. Clin Exp Immunol (2007) 147:497–503.10.1111/j.1365-2249.2006.03311.x
  • Garcia-Carrasco M, Fuentes-Alexandro S, Escarcega RO, Salgado G, Riebeling C, Cervera R. Pathophysiology of Sjogren’s syndrome. Arch Med Res (2006) 37:921–32.10.1016/j.arcmed.2006.08.002
  • Daridon C, Devauchelle V, Hutin P, Berre RL, Martins-Carvalho C, Bendaoud B. Aberrant expression of BAFF by B lymphocytes infiltrating the salivary glands of patients with primary Sjögren’s syndrome. Arthritis Rheum (2007) 56:1134–44.10.1002/art.22458
  • Groom J, Kalled SL, Cutler AH, Olson C, Woodcock SA, Schneider P. Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjogren’s syndrome. J Clin Invest (2002) 109:59–68.10.1172/JCI0214121
  • Vlachogiannis NI, Nezos A, Tzioufas AG, Koutsilieris M, Moutsopoulos HM, Mavragani CP. Increased frequency of the PTPN22W* variant in primary Sjogren’s Syndrome: association with low type I IFN scores. Clin Immunol (2016) 173:157–60.10.1016/j.clim.2016.10.015
  • Johnsen SJ, Gudlaugsson E, Skaland I, Janssen EA, Jonsson MV, Helgeland L, et al. Low protein A20 in minor salivary glands is associated with lymphoma in primary Sjögren’s Syndrome. Scand J Immunol (2016) 83(3):181–7.10.1111/sji.12405
  • Williams AEG, Choi K, Chan AL, Lee YJ, Reeves WH, Bubb MR, et al. Sjögren’s syndrome-associated microRNAs in CD14+ monocytes unveils targeted TGFβ signaling. Arthritis Res Ther (2016) 18:95.10.1186/s13075-016-0987-0
  • Cole MB, Quach H, Quach D, Baker A, Taylor KE, Barcellos LF, et al. Epigenetic signatures of salivary gland inflammation in Sjögren’s syndrome. Arthritis Rheumatol (2016) 68(12):2936–44.10.1002/art.39792
  • Wang J, Peng H, Tian J, Ma J, Tang X, Rui K, et al. Upregulation of long noncoding RNA TMEVPG1 enhances T helper type 1 cell response in patients with Sjögren syndrome. Immunol Res (2016) 64(2):489.10.1007/s12026-015-8715-4
  • Nair JJ, Singh TP. Sjogren’s syndrome: review of the aetiology, pathophysiology & potential therapeutic interventions. J Clin Exp Dent (2017) 9(4):e584–9.10.4317/jced.53605
  • Sardu C, Cocco E, Mereu A, et al. Population based study of 12 autoimmune diseases in Sardinia, Italy: prevalence and comorbidity. PLoS One. 2012;7(3):e32487.